P2‐335: ASSESSING PATIENT HEALTH RISK FACTOR BURDEN AND APOE IN SPORADIC EARLY‐ONSET AD WITH AND WITHOUT AD FAMILY HISTORY

• DOI: 10.1016/j.jalz.2018.06.1025
• Publication Date: 2018-10-22T09:30:51Z
• Authors: Viktoriya Bourakova; Joanne Taylor; Renaud La Joie; Adrienne Visani; Orit H. Lesman-Segev; Anna M. Karydas; Julie Pham; Bruce L. Miller; Gil D. Rabinovici
• Keywords: First-degree relatives; PSEN1; Family aggregation; Apolipoprotein E

The risk factors that underlie sporadic early-onset Alzheimer's disease (sEOAD) are not well understood. We compared clinical presentation, demographic features, ApoE genotype, and dementia between patients with non-autosomal AD in without a family history of the disease. A group 103 sEOAD ≤64 age onset confirmed evidence amyloidosis using available PIB-PET or CSF values were included. Patients known APP/PSEN1/PSEN2 mutations excluded. Pedigrees reviewed participants classified as: (1) no AD/dementia first second-degree relative, (2) relative. Group comparisons performed across variables (Table 1). Frequency relevant comorbid conditions also groups (Figure 1A). Results. showed lower frequency rate (27% vs. 46%) atypical (PCA, lvPPA) higher proportion E4 Carriers (59% 41%) to history. Age-of-onset stage at evaluation similar. 1).There non-significant trends for have rates thyroid (a potential marker auto-immunity young age) TBI. No other differed groups. Results similar when dividing into degree relatives. When sub-classifying each by ApoE4 there TBI carriers non-carriers 1B). EOAD was associated while absence non-amnestic presentation. Traditional late-onset do explain non-familial EOAD, suggesting novel yet be identified.