F1‐03‐03: THE ROLE OF MENINGEAL LYMPHATICS IN ALZHEIMER‐RELATED AMYLOID PATHOLOGY

• DOI: 10.1016/j.jalz.2018.06.2313
• Publication Date: 2018-10-22T10:05:41Z
• Authors: Natalia Acosta; Salli Antila; Meike H. Keuters; Flavia Scoyni; Antti-Ville Korhonen; Nea Bister; Henna Konttinen; Sara Wojciechowski; Jari Koistinaho; Kari Alitalo; Tarja Malm; Heikki Tanila
• Keywords: Lymphatic vessel

The central nervous system (CNS) has for long been considered to be devoid of proper lymphatic vascular system. However, recent studies suggest that meningeal vessels may take part into clearance waste products, macromolecules and immune cells systemic blood circulation. We set out investigate the contribution in drainage beta-amyloid (Aß) protein from brain hypothesized lack Alzheimer's disease (AD) transgenic mice would lead faster Aß accumulation. cross-bred amyloid plaque producing APPswe/PS1dE9 (APdE9) with K14-VEGFR3-Ig (K14) cutaneous due overexpression an inactivating transgene. Young adult APdE9 x K14 double showed no other signs health monitoring except modest edema on their paws abdomen. followed up male female tg wt (n = 13-14 per group) age 5.5 months when all show plaques cortex hippocampus. One hemisphere was used biochemical assays processed histology. Immunohistochemistry ELISA difference cortical load, but unexpectedly, load significantly lower hippocampus mice. are currently elucidating underlying mechanisms. Gene manipulation resulting lymphatics does affect accumulation AD mouse brain. (and cutaneous) birth induce changes make interpretation less straightforward.