Inducible hepatic expression of CREBH mitigates diet-induced obesity, insulin resistance, and hepatic steatosis in mice

• DOI: 10.1016/j.jbc.2021.100815
• Publication Date: 2021-05-21T16:38:11Z
• Authors: Christopher S. Krumm; Xu Xu; Curtis J. Bare; Corey D. Holman; Sander Kersten; Lukas E. Dow; Ann-Hwee Lee; David E. Cohen
• Keywords: FGF21; Steatosis

Cyclic AMP-responsive element-binding protein H (CREBH encoded by Creb3l3) is a transcription factor that regulates the expression of genes control lipid and glucose metabolism as well inflammation. CREBH upregulated in liver under conditions overnutrition, mice globally lacking gene