Abstract 2470 A copper-containing antibiotic produced by Pseudomonas

• DOI: 10.1016/j.jbc.2024.106244
• Publication Date: 2024-03-25T21:53:34Z
• Authors: Bo Li; William Simke; Morgan Walker; Logan Calderone; Andrew Putz; Jon Patteson; Matthew Redinbo; Maria-Eirini Pand...; Tyler Grove

Pseudomonas species colonize and infect a broad range of eukaryotic hosts. Infection by these bacteria can significantly impact the diversity composition microbiota produce many natural products, including antibiotics, toxins, signaling molecules. These molecules play essential roles in microbe-microbe microbe-host interactions. This talk describes identification, biosynthesis, activity an unusual copper-containing antibiotic, fluopsin C, produced opportunistic human pathogen aeruginosa. The biosynthesis C requires five enzyme-catalyzed reactions, unique methine excision reaction. biosynthetic gene cluster is conserved nearly 5,000 P. aeruginosa genomes distributed other pathogens plant colonizers. Thus, likely plays physiological role bacteria. work uncovers new chemistry chemical interactions between commensal microbes. supported National Institutes Health (DP2HD094657 R01GM148685 to B.L.; GM137286 M.R.R., GM111978 GM126303 M.-E.P.) Packard Fellowship Science Engineering (B.L.). T.L.G. acknowledges funding from Searle Scholars Program.