Heart Transplant and Pregnancy

• DOI: 10.1016/j.jchf.2024.11.016
• Publication Date: 2025-03-03T19:08:25Z
• Authors: Vanessa Kirschner; Ophelia Yin; Lisa Coscia; Prisca C. Diala; Negeen Shahandeh; Roxanna A. Irani; Serban Constantin...; Michael J. Moritz; Yalda Afshar

Heart transplant recipients (HTRs) during pregnancy are at greater risk for maternal and obstetrical complications hypertensive disease of exacerbates these risks. The impact preeclampsia on HTRs is unknown. authors describe characteristics who developed the effect graft outcomes. This a retrospective group study adult with subsequent outcomes ≥20 weeks' gestation enrolled in Transplant Pregnancy Registry International between 1986 2022. primary outcome was loss within 2 years from delivery. Secondary included neonatal A total 146 pregnancies 149 neonates met inclusion criteria. All were livebirths. Forty-two (28.8%) complicated by preeclampsia. more likely to be nulliparous (81.0% vs 54.8%; P < 0.01), have chronic hypertension (73.8% 34.6%; 0.01). There no difference incidence (4.8%) or without (2.9%) (P = 0.72). clinically important survival compared (adjusted HR: 0.79 [95% CI: 0.37-1.69]; 0.54). However, rates severe morbidity high both groups: 16.7% 10.6% those Furthermore, associated earlier gestational age birth (35.0 37.0 weeks; 0.01) lower weight (2,310 2,801 grams; delivery pregnancy. Regardless preeclampsia, pregnant than general population experience morbidity. These findings provide pertinent information counseling heart pursue