Independent human mesenchymal stromal cell–derived extracellular vesicle preparations differentially attenuate symptoms in an advanced murine graft-versus-host disease model

• DOI: 10.1016/j.jcyt.2023.03.008
• Publication Date: 2023-04-12T05:18:38Z
• Authors: Rabea J. Madel; Verena Börger; Robin Dittrich; Michel Bremer; Tobias Tertel; Nhi Ngo Thi Phuong; Hideo A. Baba; Lambros Kordelas; Simon Staubach; Frank Stein; Per Haberkant; Matthias Hackl; Regina Grillari; Johannes Grillari; Jan Buer; Peter A. Horn; Astrid M. Westendorf; Sven Brandau; Carsten J. Kirsch...; Bernd Giebel
• Keywords: Clinical Significance

Extracellular vesicles (EVs) harvested from conditioned media of human mesenchymal stromal cells (MSCs) suppress acute inflammation in various disease models and promote regeneration damaged tissues. After successful treatment a patient with steroid-refractory graft-versus-host (GVHD) using EVs prepared bone marrow-derived MSCs, this study focused on improving the MSC-EV production for clinical application.