Co-delivery of curcumin and resveratrol by folic acid-conjugated poly(glycerol adipate) nanoparticles for enhanced synergistic anticancer effect against osteosarcoma

• DOI: 10.1016/j.jddst.2024.105610
• Publication Date: 2024-03-23T09:30:36Z
• Authors: Amaraporn Wongrak...; Huong Bui Thi Thu; Krisada Sakchaisri; Vincenzo Taresco; Valentina Cuzzuco...; Somnuk Bunsupa; Jiraphong Suksiri...
• Keywords: Adipate; Nanocarriers

This study explored the co-delivery of curcumin (CUR) and resveratrol (RV) using folic acid-conjugated poly(glycerol adipate)-based nanoparticles (FPPC NPs) to enhance their synergistic anticancer effects against osteosarcoma. Based on toxicity experiments Saos-2 cells, optimal CUR:RV ratios were 1:2 1:3, which used for co-encapsulation. Increasing amount RV in co-loaded NPs did not affect properties nanocarriers, but predominantly increased loading capacity RV, especially at 1:3 ratio, by 1.8–2.0 times, mediated interaction. All demonstrated sustained release CUR with a burst presence accelerated initial from carriers. Furthermore, co-encapsulated maintained synergism greatly enhanced osteosarcoma least 1.8 times compared corresponding solutions through profound accumulation cells sub G1 phase late apoptosis. The internalization FPPC into via endocytosis was dose- time-dependent. offers proof-of-concept potential system tumor-targeted activity