Induced skin aging by blue-light irradiation in human skin fibroblasts via TGF-β, JNK and EGFR pathways

• DOI: 10.1016/j.jdermsci.2023.06.007
• Publication Date: 2023-06-28T06:27:23Z
• Authors: Ge Ge; Yiyu Wang; Yang Xu; Weilin Pu; Yimei Tan; Peiyi Liu; Hao Ding; Yu-Meng Lu; Jiucun Wang; Wei Liu; Yanyun Ma
• Keywords: Photoaging; Human skin; MMP1; Dermal fibroblast; Skin Aging

Studies indicate that blue light (BL) irradiation can damage human skins, but the impact of BL on skin aging is unknown.This study aimed to give an insight phenotypic characteristics and molecular mechanism light-induced aging, thus provide a theoretical basis for precise protection photodermatosis.The effect photoaging in mice was evaluated by non-invasive measurement equipment histopathology analysis. The proliferation HFF-1 cells detected Real-Time Cell Analyzer. expression protein levels genes associated with were examined.Our studies indicated caused irradiation, including collagen disorder increased MMP1. also inhibited cell fibroblasts inhibiting TGF-β signaling pathway, based vitro experiments. Importantly, promoted degradation increasing MMP1 activated JNK/c-Jun EGFR pathways. Moreover, ROS significantly after fibroblasts. Yet, transcriptional change unable be completely restored scavenger.BL down-regulated type I up-regulated inhibit Multiple key pathways TGF-β, JNK, involved BL-induced aging. Our results bases irradiation.