Exosomes containing miR-1469 regulate natural killer cells by targeting CD122 in non-segmental vitiligo

• DOI: 10.1016/j.jdermsci.2023.12.006
• Publication Date: 2023-12-24T00:46:05Z
• Authors: Yujia Wei; Ting Zhou; Ronghua Pan; Xiaoqi Nie; Zhong Liu; Zeqi Shi; Ying Zeng; Ri Zhang; Yunhua Deng; Dong Li
• Keywords: Exosome; Vitiligo; Pathogenesis

BackgroundPlasma exosomal microRNAs (miRNAs) have been used as potential biomarkers for various diseases and investigated their possible involvement in the pathogenesis of vitiligo. However, miRNA expression profile plasma exosomes patients with non-segmental vitiligo (NSV) has not determined yet.ObjectiveTo screen differentially expressed derived from NSV explore roles NSV.MethodsHigh-throughput sequencing was performed to determine profiles miRNAs NSV. The effect upregulated miR-1469 circulating on natural killer (NK) cells further using molecular biological techniques.ResultsMiR-1469 identified a candidate biomarker whose significantly increased patients. Circulating were internalized by NK cell proliferation viability IFN-γ secretion capacity delivering miR-1469. Further studies revealed that upregulation CD122, predicted target miR-1469, could partially reverse cells.ConclusionAlterations cargo occur appear contribute dysfunction. Exosomal may be disease activity therapeutic drug against innate immunity present study provides new insights into role suggests novel miR-1469-CD122-IFN-γ pathway underlying