Psoriasis and adverse pregnancy outcomes: A nationwide case-control study in 491,274 women in Denmark

• DOI: 10.1016/j.jdin.2022.03.009
• Publication Date: 2022-04-19T09:22:40Z
• Authors: Cæcilie Bachdal J...; Alexander Egeberg; Espen Jimenez-Solem; Lone Skov; Simon Francis Tho...
• Keywords: pregnancy outcome; psoriasis; 3. Good health; 03 medical and health sciences; spontaneous abortion; 0302 clinical medicine; psoriasis severity; ectopic pregnancy; stillbirth; Original Article; pregnancy; women; fetal death

The chronic systemic inflammation associated with psoriasis supposedly creates an undesirable milieu for a pregnancy, resulting in increased risk of adverse pregnancy outcomes (APOs).To investigate the association between and APOs as well how differs according to severity (mild moderate-to-severe).This nationwide register-based case-control study collected data from 1973 2017. Cases were (spontaneous abortion, ectopic [EP], intrauterine fetal death, stillbirth). Singleton live births controls. Adjusted logistic regression models used statistical analyses.In total, 42,041 (8.56%) 449,233 (91.44%) controls included. EP was only APO that found be statistically (odds ratio, 1.34; 95% CI, 1.06-1.68). Odds ratio highest women moderate-to-severe 2.77; 1.13-6.76). absolute 2.48% higher compared without (3.98% vs 1.50%).No access clinical confirming severity.The present significant (absolute 3.98%). As is leading cause maternal morbidity mortality first trimester our findings call particular care reproductive age psoriasis.