Analgesic and anti-inflammatory activities of 11-O-galloylbergenin

• DOI: 10.1016/j.jep.2010.06.040
• Publication Date: 2010-07-06T08:28:41Z
• Authors: Mohammad Arfan; Hazrat Amin; Nematullah Khan; Inamullah Khan; Muhammad Saeed; Muhammad Azim Khan; Fazal-ur-Rehman
• Keywords: Mallotus; Carrageenan; Anti-inflammatory; Hot plate test

Current study was designed to explore the analgesic and anti-inflammatory effects of a constituent isolated from Mallotus philippinensis, in order to validate its folk use.11-O-galloylbergenin was isolated from ethanolic extract of Mallotus philippinensis. Analgesic and anti-inflammatory activities of the test compound were assessed using formalin test and carrageenan-induced paw edema models.11-O-galloylbergenin showed significant analgesic activity at doses of 20 and 40 mg/kg against formalin test in rats. Similarly, 11-O-galloylbergenin exhibited significant anti-inflammatory activity in carrageenan-induced paw edema model at doses of 10, 20 and 30 mg/kg.11-O-galloylbergenin has demonstrated its significant potential to be further investigated for its discovery as a new lead compound for management of pain and inflammation.