Burdock fructooligosaccharide as an α-glucosidase inhibitor and its antidiabetic effect on high-fat diet and streptozotocin-induced diabetic mice

• DOI: 10.1016/j.jff.2021.104703
• Publication Date: 2021-08-30T21:40:45Z
• Authors: Ping-chuan Yuan; Tai-li Shao; Jun Han; Chun-yan Liu; Guo-dong Wang; Shu-guang He; Shi-xia Xu; Si-hui Nian; Kao-shan Chen
• Keywords: Fructooligosaccharide; Malondialdehyde; High-density lipoprotein

Burdock roots are rich in inulin-type burdock fructooligosaccharide (BFO). However, the antidiabetic effect of BFO remains unknown. In this study, was purified using DEAE-52 and G-75. The purity 99.4%, peak-average molecular weight (Mp) 2958 Da. inhibited α-glucosidase activity with an IC50 0.4996 mg/mL. Streptozotocin (STZ) high-fat diet (HFD) induced diabetic mice were used to test anti BFO. reduced fasting blood glucose (FBG) levels, relieved rapid loss, improved tolerance after six weeks treatment. addition, serum triglyceride (TG), total cholesterol (TC), low-density lipoprotein (LDL-C), reactive oxygen species (ROS), malondialdehyde (MDA), nitric oxide synthetase (NOS) while increasing superoxide dismutase (SOD) high-density (HDL-C) levels. also islet, liver, kidney damage. Based on these findings, possesses potent effects mice.