Effects of blue honeysuckle containing anthocyanin on anti-diabetic hypoglycemia and hyperlipidemia in ob/ob mice

• DOI: 10.1016/j.jff.2022.104959
• Publication Date: 2022-01-22T04:46:33Z
• Authors: Hyun Jeong Lee; Da-Yeon Lee; Yoon-Seok Chun; Jong-Kyu Kim; Jung-Ok Lee; Sae-Kwang Ku; Soon-Mi Shim
• Keywords: Hyperlipidemia; Lipogenesis

The purpose of the current study was to observe anti-diabetic and anti-obesity effects blue honeysuckle (BH; Lonicera caerulea L.) extracts on obese diabetic mice. BH dose-dependently significantly inhibited abnormal endocrine pancreas histopathological changes. Moreover, favorable non-alcoholic fatty liver disease, nephropathy, hyperlipidemia refinement activities in were shown be dose dependent. Particularly, extract 200 mg/kg showed modulatory PPAR γ AMPK hepatic adipose tissues as comparable those positive control, conjugated linoleic acid (CLA) administration. Results from suggest that could a potential functional ingredient for through inhibition lipogenesis glucose production by regulating lipid metabolism-related mRNA expressions.