Biometabolites of Tamarindus indica play a remarkable cardioprotective role as a functional food in doxorubicin-induced cardiotoxicity models

• DOI: 10.1016/j.jff.2022.105212
• Publication Date: 2022-08-09T00:19:57Z
• Authors: Hashi Akter; Md. Mamunur Rashid; Md. Shahidul Islam; Md. Amjad Hossen; Md. Atiar Rahman; Reham M. Algheshairy; Mona S. Almujaydil; Hend F. Alharbi; Afnan M. Alnajeebi
• Keywords: Cardiotoxicity

This research investigated the cardioprotective effects of Tamarindus indica extracts (TIEx) in doxorubicin (Dox)-induced cardiotoxicity model. TIEx was tested for phytochemical and antioxidative status followed by a randomized controlled intervention Swiss albino models. The results were verified silico interactions GC-MS characterized phytocompounds against AT1 (angiotensin II type 1) receptor antagonist complexed with PPARγ agonist. showed an excellent effect significant (P < 0.05) decrease C-reactive protein (CRP), Serum troponin I (STI), aspartate transaminase (AST), lactate dehydrogenase (LDH), creatinine kinase-MB (CKMB), total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL) increase high-density (HDL) treatment groups comparison standard drug valsartan. selected bioactive compounds especially Thymine, 4H-Pyran-4-one, 2,3-dihydro-3,5-dihydroxy-6-methyl- highest binding affinity human Results demonstrate that parts could be food supplement cardiac toxicity.