MiR-22-3p modulated the antioxidant activity of curcumin via targeting the cardiolipin synthase gene CRLS1 in LO2 cells

• DOI: 10.1016/j.jff.2023.105541
• Publication Date: 2023-04-20T07:02:01Z
• Authors: Xiaoting Sun; Yuanyuan Li; Yanqi Lin; Yuanyuan Mei; Lingli Lin; Kuo-Ting Ho; Kaiyan Huang; Jialin Zhan; Chaoxiang Chen; Jun Zeng; Daren Wu; Jian Li; Jingwen Liu; Guiling Li
• Keywords: Polyphenol; MicroRNAs; 0303 health sciences; 03 medical and health sciences; Nutrition. Foods and food supply; Antioxidation; TX341-641; Reactive oxygen species; Mitochondria

The antioxidant activity of curcumin has been extensively investigated for years. However, its molecular function mechanism remained unclear. Our preliminary study showed that downregulated miR-22-3p expression. This aimed to address whether mediated the and possible action mechanism. results repression increased total cellular capacity enhanced endogenous enzyme system LO2 cells. In addition, miR-22-3p-deteriorated was prevented by pretreatment. Moreover, inhibition significantly improved mitochondrial biogenesis. Further investigation demonstrated a key regulator, cardiolipin synthase gene (CRLS1), targeted miR-22-3p. CRLS1 overexpression also biogenesis in Taken together, all these data suggested modulated effect via targeting CRLS1, which may provide novel insights into miRNA-mediated curcumin.