Supplementation of cyanidin-3-O-β-glucoside-rich haskap (Lonicera caerulea L.) berry extract attenuates hepatic lipid dysregulation in diet-induced obese mice

• DOI: 10.1016/j.jff.2023.105635
• Publication Date: 2023-08-19T15:08:17Z
• Authors: Dipsikha Biswas; A.B.K.H. De Silva; Angella Mercer; Shreya Sarkar; Petra Kienesberger; Morgan Langille; H.P.Vasantha Rupa...; Thomas Pulinilkunnil
• Keywords: Anthocyanin; Nutrition. Foods and food supply; Diabetes; Haskap; TX341-641; Obesity; Cyanidin; Western diet

Haskap (Lonicera caerulea L.) berry is enriched in anthocyanins, primarily cyanidin-3-O-β-glucoside (C3G). It remains unknown whether C3G counteracts metabolic alterations of the pathogenesis obesity. In this study, mice were fed high-fat high-sucrose (HFHS) diet supplemented either with C3G-rich extract (HFHS + CE) or powder low BP). Mice HFHS CE displayed short-term protection against weight gain, independent food intake. had lower hepatic diacylglycerols and triacylglycerols content reduced expression key lipogenic transcription factors. These changes also translated into improved glucose tolerance insulin sensitivity. 16S rRNA sequencing revealed altered gut microbiota composition group. summary, we demonstrate that enrichment attenuates decreases lipid by suppressing gene improves homeostasis during obesity development, supporting therapeutic utility as a bioactive phytonutrient to manage obesity-related complications.