Genetic characterization of a Salmonella enterica serovar Typhimurium isolated from an infant with concurrent resistance to ceftriaxone, ciprofloxacin and azithromycin

• DOI: 10.1016/j.jgar.2023.09.016
• Publication Date: 2023-09-30T01:07:58Z
• Authors: Meiling Liu; Kunpeng Zhu; Xinge Li; Yiran Han; Chaojie Yang; Hongbo Liu; Xinyin Du; Xuebin Xu; Haiyan Yang; Hongbin Song; Shaofu Qiu; Ying Xiang
• Keywords: Salmonella enterica

To investigate the resistance mechanism of a Salmonella Typhimurium (S. Typhimurium) isolated from faecal sample an infant, which exhibited concurrent to ceftriaxone, ciprofloxacin and azithromycin. Antimicrobial susceptibility testing was performed by broth microdilution in two kinds drug-sensitive plates. (AMR) genes were identified whole genome sequencing bioinformatics analysis. Genotyping strain multilocus sequence typing (MLST). Plasmid DNA sequenced analysed using plasmid tools. The SH11G993 resistant 28 antibiotics carried 54 AMR genes. MLST results showed that belonged rare genotype. profile plasmids. pSH11G993-1 14 (especially co-harboured blaCMY-2, mphA ermB) variety insertion sequences, belonging IncC. pSH11G993-2 3 9 virulence genes, IncFIB-FII, forming novel co-harbouring plasmid. Our findings highlight continuously monitor changes antibiotic patterns research on mechanisms potential human pathogens are imperative.