Ginseng-plus-Bai-Hu-Tang ameliorates diet-induced obesity, hepatic steatosis, and insulin resistance in mice

• DOI: 10.1016/j.jgr.2018.10.005
• Publication Date: 2018-10-27T02:04:57Z
• Authors: Hsu-Feng Lu; Yu-Heng Lai; Hsiu-Chen Huang; I-Jung Lee; Lie-Chwen Lin; Hui-Kang Liu; Hsiao-Hsuan Tien; Cheng Huang
• Keywords: Steatosis; Dyslipidemia; Hyperlipidemia

Dietary fat has been suggested to be the cause of various health issues. Obesity, hypertension, cardiovascular disease, diabetes, dyslipidemia, and kidney disease are known associated with a high-fat diet (HFD). Obesity conditions, such as type 2 diabetes mellitus nonalcoholic fatty liver (NAFLD), currently worldwide problem. Few prospective pharmaceutical therapies that directly target NAFLD available at present. A Traditional Chinese Medicine, ginseng-plus-Bai-Hu-Tang (GBHT), is widely used by diabetic patients control glucose level or thirst. However, whether it therapeutic effects on fat-induced hepatic steatosis metabolic syndrome remains unclear.This study was conducted examine effect GBHT obesity, steatosis, insulin resistance in mice.GBHT protected mice against HFD-induced body weight gain, hyperlipidemia, hyperglycemia compared were not treated. inhibited expansion adipose tissue adipocyte hypertrophy. No ectopic deposition found livers HFD treated GBHT. In addition, intolerance sensitivity also improved GBHT.GBHT prevents changes lipid carbohydrate metabolism mouse model. Our findings provide evidence for traditional use therapy management syndrome.