Effect of Korea red ginseng on nonalcoholic fatty liver disease: an association of gut microbiota with liver function

• DOI: 10.1016/j.jgr.2020.07.004
• Publication Date: 2020-07-16T02:14:43Z
• Authors: Ji Taek Hong; Min-Jung Lee; Sang Jun Yoon; Seok Pyo Shin; Chang Seok Bang; Gwang Ho Baik; Dong Joon Kim; Gi Soo Youn; Min Jea Shin; Young Lim Ham; Ki Tae Suk; Bong-Soo Kim
• Keywords: Lachnospiraceae; Liver function

Korea Red Ginseng (KRG) has been used as remedies with hepato-protective effects in liver-related condition. Microbiota related gut-liver axis plays key roles the pathogenesis of chronic liver disease. We evaluated effect KRG on patients nonalcoholic statohepatitis by modulation gut-microbiota.A total 94 (KRG: 45 and placebo: 49) were prospectively randomized to receive (2,000 mg/day, ginsenoside Rg1+Rb1+Rg3 4.5mg/g) or placebo during 30 days. Liver function test, cytokeraton 18, fatigue score measured. Gut microbiota was analyzed MiSeq systems based 16S rRNA genes.In group, mean levels (before vs. after) aspartate aminotransferase (53 ± 19 23 IU/L), alanine (75 40 64 39 IU/L) (33 13 26 13) improved (p < 0.05). In only (34 31 15) ameliorated The changes phyla not statistically significant both groups. increased abundance Lactobacillus level Clostridium Intestinibacter associated no improvement after supplementation. Lachnospiraceae could be aggravation enzyme 0.05).KRG effectively enzymes modulating gut-microbiota fatty Further studies are needed understand mechanism steatohepatitis.NCT03945123 (www.ClinicalTrials.gov).