Endocrine disrupting potential of total and bioaccessible extracts of dust from seven different types of indoor environment

• DOI: 10.1016/j.jhazmat.2024.133778
• Publication Date: 2024-02-16T11:25:14Z
• Authors: Felipe Augusto Pi...; Jiří Novák; Simona Rozárka Jí...; Tatsiana Rusina; Branislav Vrana; Lisa Melymuk; Klára Hilscherová
• Keywords: Air Pollution, Indoor; Androgens; Indoor dust; Bioaccessibility; Endocrine disrupting chemicals; Human risk assessment; In vitro; Humans; Dust; Environmental Pollutants; Endocrine System; Estrogens; Child; 01 natural sciences; 0105 earth and related environmental sciences

Information on the indoor environment as a source of exposure with potential adverse health effects is mostly limited to few pollutant groups and types. This study provides comprehensive toxicological profile chemical mixtures associated dust from various types environments, namely cars, houses, prefabricated apartments, kindergartens, offices, public spaces, schools. Organic extracts two different polarities bioaccessible mimicking gastrointestinal conditions were prepared particle size fractions dust. These tested battery human cell-based bioassays assess endocrine disrupting potentials. Furthermore, 155 chemicals measured their relevance for bioactivity was determined using concentration addition modelling. The exhaustive microenvironments interfered aryl hydrocarbon receptor, estrogen, androgen, glucocorticoid, thyroid hormone (TH) receptor signalling, TH transport. Noteably, offices spaces showed higher estrogenic than organic solvent extracts. 114 targeted detectable, but observed could be only marginally explained by detected chemicals. Diverse toxicity patterns across that people inhabit throughout lifetime indicate developmental risks, especially children. Limited data potency relevant classes, those deployed replacements legacy contaminants, requires further study.