Comparison of the Inflammatory Circuits in Psoriasis Vulgaris, Non‒Pustular Palmoplantar Psoriasis, and Palmoplantar Pustular Psoriasis

• DOI: 10.1016/j.jid.2022.05.1094
• Publication Date: 2022-08-05T02:36:33Z
• Authors: Claire Q. Wang; Sokol Haxhinasto; Sandra Garcet; Norma Kunjravia; Inna Cueto; Juana Gonzalez; Darshna Rambhia; Olivier Harari; Matthew A. Sleeman; Jennifer D. Hamilton; Wei Keat Lim; Jan Freudenberg; George D. Kalliolias; Paresh Thakker; Robert Bissonnette; James G. Krueger
• Keywords: Palmoplantar pustulosis

Palmoplantar pustular psoriasis (PPPP) and non‒pustular palmoplantar (NPPP) are localized, debilitating forms of psoriasis. The inflammatory circuits involved in PPPP NPPP not well-understood. To compare the cellular immunological features that differentiate NPPP, skin biopsies were collected from a total 30 participants with PPPP, vulgaris (PV) 10 healthy participants. A subset consented to second biopsy after 3 additional weeks off medication. Histologic staining lesional nonlesional showed higher neutrophil counts than PV CD8+ T-cell NPPP. RNA sequencing transcriptional analysis enhanced IFN-γ pathway activation lesions but stronger signatures IL-17 neutrophil-related genes (e.g., IL36A) skin. Serum on Olink platform detected concentrations T helper type 1, IFN-γ‒inducible chemokines neutrophil-associated cytokines PPPP. Taken together, this evidence suggests more pronounced 1‒mediated inflammation activity PV. These data support targeting pathways associated neutrophilic IL-36 signaling) for therapeutic development