Functional Interplay between IL-9 and Peptide YY Contributes to Chronic Skin Inflammation

• DOI: 10.1016/j.jid.2022.06.021
• Publication Date: 2022-07-16T08:37:08Z
• Authors: Shiori Kamiya; Ippei Ikegami; Masahiro Yanagi; Hiromi Takaki; Ryuta Kamekura; Taiki Sato; Keiju Kobayashi; Takafumi Kamiya; Yuka Kamada; Takaya Abe; Ken-ichi Inoue; Tokimasa Hida; Hisashi Uhara; Shingo Ichimiya
• Keywords: Proinflammatory cytokine; Peptide YY; Epidermis (zoology)

Complex interactions between keratinocytes and various cell types, such as inflammatory cells stromal cells, contribute to the pathogenesis of chronic skin lesions. In proinflammatory cytokine‒mediated disease settings, IL-9 plays a pathological role in dermatitis. However, IL-9‒related mechanisms remain incompletely understood. this study, we established tamoxifen-induced keratinocyte-specific IL-9RA-deficient mice (K14CRE/ERTIl9raΔ/Δ mice) examine multicellular under conditions. Studies using an imiquimod-induced psoriasis-like model showed that K14CRE/ERTIl9raΔ/Δ exhibited significantly reduced severity dermatitis mast infiltration compared with control K14WTIl9rafl/fl mice. Transcriptome analyses lesions level peptide Y-Y (Pyy), member neuropeptide Y family, was markedly downregulated epidermis. Pyy blockade suppressed epidermal thickening numbers imiquimod-treated wild-type Together vitro studies indicating induced production chemotactic activity bone marrow‒derived these findings suggest Pyy-mediated interplay contributes psoriasiform inflammation. Further investigation focusing on IL-9‒Pyy axis may provide valuable information for development new treatment modalities