Patient-Derived Xenograft and Cell Line Models of Human Primary Cutaneous Diffuse Large B-Cell Lymphoma-Leg Type

• DOI: 10.1016/j.jid.2022.08.043
• Publication Date: 2022-09-07T03:46:23Z
• Authors: Martina Prochazko...; Audrey Gros; Elodie Richard; Floriane Cherrier; Elodie Laharanne; Yamina Idrissi; Camille Baron; Sandrine Poglio; Océane Ducharme; Sarah Menguy; Anne Pham-Ledard; Marie Beylot-Barry; Jean-Philippe Merlio; Laurence Bresson-...
• Keywords: Leg; Disease Models, Animal; 0303 health sciences; 03 medical and health sciences; Skin Neoplasms; Humans; Animals; Heterografts; Lymphoma, Large B-Cell, Diffuse; Cell Line

Primary cutaneous diffuse large B-cell lymphoma, leg-type (PCDLBCL-LT) is a rare and aggressive malignancy, mostly occurring on the leg of elderly women (Willemze et al., 2019). PCDLBCL-LT harbors an activated B-cell‒like lymphoma (ABC-DLBCL) signature enriched for mutations involving toll-like receptor, NF-κB pathways (Pham-Ledard 2012; Zhou 2018). The high frequency MYD88L265P mutation in combination with those CD79B PIM1 relates these lymphomas to MCD/C5 subset lymphomas, which includes ABC-DLBCL extranodal sites (Danilov 2022).