Disease Association of Anti‒Carboxyethyl Lysine Autoantibodies in Hidradenitis Suppurativa

• DOI: 10.1016/j.jid.2022.08.051
• Publication Date: 2022-09-16T03:20:17Z
• Authors: Giulio Macchiarella; Vanessa Cornacchione; Celine Cojean; Julia Riker; Yichen Wang; Helene Te; Melanie Ceci; Johann E. Gudjonsson; Swann Gaulis; Jean François Goe...; Audrey Wollschlegel; Stephanie K. Gass; Sofia Oetliker-Co...; Barbara Wettstein...; Dirk J. Schaefer; Pascale Meschberger; Roland de Roche; Rik Osinga; Grazyna Wieczorek; Ulrike Naumann; Joachim C.U. Lehmann; Anna Schubart; Andreas Hofmann; Lukas Roth; Edwin F. Florencia; Christian Loesche; Elisabetta Traggiai; Alexandre Avrameas; Errol P. Prens; Till A. Röhn; Ben Roediger
• Keywords: Hidradenitis Suppurativa

Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease characterized by recurring suppurating lesions of the intertriginous areas, resulting in substantial impact on patients' QOL. HS pathogenesis remains poorly understood. An autoimmune component has been proposed, but disease-specific autoantibodies, autoantigens, or autoreactive T cells have yet to be described. In this study, we identify high prevalence IgM, IgG, and IgA antibodies directed against Nε-carboxyethyl lysine (CEL), methylglyoxal-induced advanced glycation end-product, sera patients with HS. Titers anti-CEL IgG were highly elevated compared those healthy controls individuals other diseases. Strikingly, majority was IgG2 subclass correlated independently both severity duration. Both CEL anti-CEL‒producing plasmablasts could isolated directly from lesions, further confirming relevance response. Our data point an aberration methylglyoxal pathway support axis debilitating disease.