Post-acute COVID-19 syndrome. Incidence and risk factors: A Mediterranean cohort study

• DOI: 10.1016/j.jinf.2021.01.004
• Publication Date: 2021-01-13T06:38:55Z
• Authors: Oscar Moreno-Pérez; Esperanza Merino; Jose-Manuel Leon-...; Mariano Andres; Jose Manuel Ramos; Juan Arenas-Jiménez; Santos Asensio; Rosa Sanchez; Paloma Ruiz-Torre...; Irene Galan; Alexander Scholz; Antonio Amo; Pilar González-de...; Vicente Boix; Joan Gil
• Keywords: Seroconversion

This study aims to analyze the incidence of Post-acute COVID-19 syndrome (PCS) and its components, evaluate acute infection phase associated risk factors.A prospective cohort adult patients who had recovered from (27th February 29th April 2020) confirmed by PCR or subsequent seroconversion, with a systematic assessment 10-14 weeks after disease onset. PCS was defined as persistence at least one clinically relevant symptom, abnormalities in spirometry chest radiology. Outcome predictors were analyzed multiple logistic regression (OR; 95%CI).Two hundred seventy seven mild (34.3%) severe (65.7%) forms SARS-CoV-2 evaluated 77 days (IQR 72-85) detected 141 (50.9%; 95%CI 45.0-56.7%). Symptoms mostly mild. Alterations noted 25/269 (9.3%), while radiographs 51/277 (18.9%). No baseline clinical features behaved independent development.A half COVID19 survivors. Radiological spirometric changes observed less than 25% patients. development.