Cobalt(III)-py2en systems as potential carriers of β-ketoester-based ligands

• DOI: 10.1016/j.jinorgbio.2023.112345
• Publication Date: 2023-08-02T07:03:32Z
• Authors: Marcos V. Palmeir...; Ana B. Caballero; Piedad Herrera-Ra...; Analu R. Costa; Savyo S. Santana; Guilherme P. Guedes; Amparo Caubet; Alzir Azevedo Bat...; Patrick Gamez; Mauricio Lanznaster
• Keywords: Ethylene diamine; Perchlorate

Two cobalt(III) complexes containing different β-ketoesters, namely [CoIII(L1)(py2en)](ClO4)2·H2O (1) and [CoIII(L2)(py2en)](ClO4)2 (2) (py2en = N,N′-bis(pyridin-2-ylmethyl)ethylenediamine; L1− methylacetoacetate; L2− ethyl 4-chloroacetoacetate) have been prepared investigated as prototypes of bioreductive prodrugs. The presence β-ketoester py2en ligands in 1 2, well the perchlorate counterions, was supported by IR spectroscopy CHN elemental analysis. composition molecular structure both confirmed NMR ESI mass spectrometry. Structural information also obtained for 2 via X-ray diffraction redox properties indicate that are suitable reduction under biological conditions. Investigation DNA-interacting suggest bind DNA electrostatic forces. Both may be employed possible platforms delivery biologically active compounds, since their reaction with ascorbic acid PBS at pH 6.2 7.4 37°C results release upon Co(III)/Co(II) reduction.