Validity of hepatitis B and hepatitis C case definitions

• DOI: 10.1016/j.jiph.2019.01.061
• Publication Date: 2019-02-13T10:32:52Z
• Authors: Zoran Dakic; Predrag Duric; Milotka Fabri; Fiona O’May
• Keywords: Hepatitis B; Hepatitis C; Liver disease; Viral Hepatitis

Globally, an estimated 257 million people are living with chronic hepatitis B (HBV) infection and 71 the C virus (HCV). The true public health dimensions impact of epidemics poorly understood. Case definitions fundamental parts disease surveillance, representing sets standardised criteria used to assess whether or not a person has certain disease. study evaluated sensitivity specificity case definitions, current at time data collection, recommended by European Commission (EC) Centers for Disease Prevention Control (CDC).The involved 150 hospital referrals suspected cases from Serbian clinic during 2014/2015. were tested their sensitivity, specificity, positive negative predictive values.EC 2008 CDC 2012 acute B, definition probable have low sensitivity. which rely on laboratory confirmation only maximal EC showed confirmed cases. (36.8%) value (65.6%) Hepatitis requiring presence clinical high resulting absence any manifestation, but values.Syndromic show limited use. They highlight importance diagnostics (offering values), as well need universal only.