The maternal blood lipidome is indicative of the pathogenesis of severe preeclampsia

• DOI: 10.1016/j.jlr.2021.100118
• Publication Date: 2021-09-20T06:09:08Z
• Authors: Bing He; Yu Liu; Mano R. Maurya; Paula Benny; Cameron Lassiter; Hui Li; Shankar Subramaniam; Lana X. Garmire
• Keywords: Lipidome; Pathogenesis

Preeclampsia is a pregnancy-specific syndrome characterized by hypertension and proteinuria after 20 weeks of gestation. However, it not well understood what lipids are involved in the development this condition, even less known how these mediate its formation. To reveal relationship between preeclampsia, we conducted lipidomic profiling maternal sera 44 severe preeclamptic healthy pregnant women from multi-ethnic cohort Hawaii. Correlation network analysis showed that oxidized phospholipids (OxPLs) have increased inter-correlations connections while other lipids, including triacylglycerols (TAGs), reduced correlations connections. A total 10 lipid species demonstrate significant changes uniquely associated with preeclampsia but any clinical confounders. These classes lysophosphatidylcholines (LPC), phosphatidylcholines (PC), cholesterol esters (CE), phosphatidylethanolamines (PE), lysophosphatidylethanolamines (LPE) ceramides (Cer). random forest (RF) classifier built on shows highly accurate specific prediction (F1 statistic 0.94, balanced accuracy 0.88) demonstrating their potential as biomarkers for condition. enriched dysregulated biological pathways insulin signaling, immune response, phospholipid metabolism. Moreover, causality inference various PCs LPCs through PC 35:1e. Our results suggest lipidome may play role serve pathogenesis preeclampsia.