Elevated lipoprotein(a) as a predictor for coronary events in older men

• DOI: 10.1016/j.jlr.2022.100242
• Publication Date: 2022-06-18T01:38:29Z
• Authors: Francesca Bartoli...; Mandy E. Turner; Jonas Zimmer; Roland Chapurlat; Tan Pham; Masanori Aikawa; Aruna D. Pradhan; Pawel Szulc; Elena Aikawa
• Keywords: Male; dyslipidemia; QD415-436; CVD; Biochemistry; Risk Assessment; acute coronary syndrome; 3. Good health; lipoproteins; 03 medical and health sciences; 0302 clinical medicine; lipoprotein(a); Risk Factors; Humans; Patient-oriented and Epidemiological Research; Prospective Studies; atherosclerosis; Biomarkers; Aged; Lipoprotein(a)

Elevated circulating lipoprotein (a) [Lp(a)] is associated with an increased risk of first and recurrent cardiovascular events; however, the effect baseline Lp(a) levels on long-term outcomes in elderly population not well understood. The current single-center prospective study evaluated association incident acute coronary syndrome to identify populations at future events. concentration was assessed 755 individuals (mean age 71.9 years) within community followed for up 8 years (median time event, 4.5 years; interquartile range, 2.5–6.5 years). Participants clinically relevant high (>50 mg/dl) had absolute incidence rate ASC 2.00 (95% CI, 1.0041) over (P = 0.04). Moreover, Kaplan-Meier cumulative event analyses demonstrated when compared patients low (<30 elevated (30–50 (Gray's test; P 0.16). Within adjusted BMI, hazard ratio 2.04 1.0–4.2; 0.05) versus groups. Overall, this adds support recent guidelines recommending a one-time measurement assessment subpopulations underscores potential utility marker even among older potent Lp(a)-lowering agents are undergoing evaluation clinical use.