Lipoprotein(a), family history of cardiovascular disease, and incidence of heart failure

• DOI: 10.1016/j.jlr.2023.100398
• Publication Date: 2023-06-03T14:58:09Z
• Authors: Hai-Peng Wang; Na Zhang; Yu-Jie Liu; Tian-Long Xia; Guo-Chong Chen; Jing Yang; Fu-Rong Li
• Keywords: Lipoprotein(a)

Lipoprotein(a) (Lp(a)) is a largely genetically determined biomarker for cardiovascular disease (CVD), while its potential interplay with family history (FHx) of CVD, measure both genetic and environmental exposures, remains unclear. We examined the associations Lp(a) in terms circulating concentration or polygenetic risk score (PRS), FHx CVD incident heart failure (HF). Included were 299,158 adults from UK Biobank without known HF at baseline. Hazards ratios (HRs) 95% Cls estimated by Cox regression models adjusted traditional factors defined Atherosclerosis Risk Communities study score. During 11.8-year follow-up, 5,502 incidents occurred. Higher levels Lp(a), PRS, positive associated higher risks HF. Compared individuals who had lower no FHx, HRs (95% CIs) 1.36 (1.25, 1.49), 1.31 (1.19, 1.43), 1.42 (1.22, 1.67) those all members, parents, siblings, respectively; similar results observed using PRS. The estimates elevated attenuated after excluding myocardial infarction (MI) during follow-up. independent HF, highest was among factors. association may be partly mediated infarction.