Long-term retention of dextran-coated magnetite nanoparticles in the liver and spleen

• DOI: 10.1016/j.jmmm.2003.12.852
• Publication Date: 2004-02-05T10:35:04Z
• Authors: L.M. Lacava; V.A.P. Garcia; S. Kückelhaus; R.B. Azevedo; N. Sadeghiani; N. Buske; P.C. Morais; Z.G.M. Lacava
• Keywords: Magnetite Nanoparticles; Biocompatible material

Abstract A dextran-coated, magnetite-based magnetic fluid sample (DexMF) was tested through morphological analysis of mice organs. Clusters of magnetic nanoparticles (MNPs) were observed in liver and spleen tissues from 1 h up to 6 months after DexMF administration. In spite of long-term retention of MNPs, no morphological alterations, including damaged cells, were observed in the analyzed organs. The data suggest that DexMF sample is biocompatible and adequate for further biomedical tests.