Design and evaluation of sodium alginate/polyvinyl alcohol blend hydrogel for 3D bioprinting cartilage scaffold: molecular dynamics simulation and experimental method

• DOI: 10.1016/j.jmrt.2021.12.130
• Publication Date: 2021-12-31T07:28:40Z
• Authors: Qinghua Wei; Rongbin Yang; Daocen Sun; Jiayi Zhou; Mingyang Li; Yingfeng Zhang; Yanen Wang
• Keywords: Polyvinyl Alcohol; 3D bioprinting; Sodium alginate

To determine the optimum composition of AS/PVA for bioprinting cartilage scaffold, a molecular simulation combining experimental method was employed to investigate microstructure, physicochemical properties and printability blending hydrogels at different compositions. The compatibility analysis results show that SA PVA have good compatibility, they are miscible any Mechanical indicates tensile strength 8SA/2PVA is best, compared with 8SA/2PVA, 7SA/3PVA possesses better toughness similar strength. Moreover, FFV value pore size decrease increase content, indicating incorporation makes system denser smaller, hydrogel optimal structure proliferation chondrocytes. main reason behind conclusions obtained above attributed strong hydrogen bond intermolecular interaction between chains. Finally, that, due fluidity PVA, forming quality becomes worse when content in precursors within 30 wt.%, relatively good. Comprehensive considering above, blend selected out considered be most suitable 3D printing scaffolds.