Design on antibacterial and cytocompatible TiO2-CuxO/Ag coating through regulation of ions release

• DOI: 10.1016/j.jmrt.2024.04.073
• Publication Date: 2024-04-17T00:24:27Z
• Authors: Junqiang Wang; Yan Zhu; Guodong Zhang; Jinkun Liu; Tao Shen; Xinyuan Wei
• Keywords: TiO2-CuxO/Ag multifunctional coating; Mining engineering. Metallurgy; TN1-997; Synergistic action; Antibacterial activity; Ions release behaviors; 01 natural sciences; Magnetron sputtering; Cell proliferation; 0104 chemical sciences

Developing antibacterial and biocompatible coatings remains a challenge. A promising new thought is addressed to control the ion release behaviors through design of phases, structures, morphologies products. In this study, TiO2-CuxO/Ag were prepared via co-sputtering combined with annealing, changes brought by different annealing temperatures characterized, physical, electrochemical, properties concerned, relationship between biological performance ions-releasing behavior was investigated. Results showed that performed larger Ag particles seeded like islands on dense CuO, such features improved hydrophilicity corrosion resistance Ti substrate. Rising temperature further enhanced surface roughness, hydrophilicity, Young's modulus, hardness, dynamic coefficient friction coatings. Within initial 3 h soaking, both metal ions contributed playing roles produced synergistic enhancement effect satisfy reduction Staphylococcus aureus 99.9%. next 3∼120 releasing suppressed Cu maintained its slow stable trend, which made sure MC3T3-E1 cells could proliferate adhere negatively charged coating surface, copper oxide nanoparticles phagocytized cells. Among all coatings, M500 sample displayed superior performances contact angle, mechanical also realized aim killing pathogenic bacteria first then activating cell survival, enabled it be potentially applied in clinical treatment.