CSF chemokine levels in relapsing neuromyelitis optica and multiple sclerosis

• DOI: 10.1016/j.jneuroim.2003.12.010
• Publication Date: 2004-02-06T10:17:37Z
• Authors: Koichi Narikawa; Tatsuro Misu; Kazuo Fujihara; Ichiro Nakashima; Shigeru Sato; Yasuto Itoyama
• Keywords: Male; Multiple Sclerosis; Neuromyelitis Optica; Enzyme-Linked Immunosorbent Assay; Statistics, Nonparametric; 3. Good health; 03 medical and health sciences; 0302 clinical medicine; Humans; Female; Age of Onset; Chemokines

The pathogenesis of relapsing neuromyelitis optica (RNMO) remains unknown. We, for the first time, studied the levels of four chemokines in the cerebrospinal fluid in RNMO with ELISA and compared the data with those in multiple sclerosis (MS) and control. CXCL10/IP-10 and CCL17/TARC were significantly elevated in both RNMO and MS. Conversely, CCL2/MCP-1 was significantly lower in MS, but not in RNMO, than in control. CCL11/Eotaxin was not different between groups. None of the four chemokines studied was significantly different between RNMO and MS.