Analysis of apoptosis-related genes in patients with clinically isolated syndrome and their association with conversion to multiple sclerosis

• DOI: 10.1016/j.jneuroim.2015.02.006
• Publication Date: 2015-02-24T23:39:26Z
• Authors: Sanna Hagman; Marcin Kolasa; Pabitra Basnyat; Mika Helminen; Mika Kähönen; Prasun Dastidar; Terho Lehtimäki; Irina Elovaara
• Keywords: Adult; Male; Multiple Sclerosis; Caspase 1; NF-kappa B; Apoptosis; Receptors, Death Domain; Middle Aged; Magnetic Resonance Imaging; 3. Good health; CARD Signaling Adaptor Proteins; Cohort Studies; Transforming Growth Factor beta1; Cytoskeletal Proteins; 03 medical and health sciences; 0302 clinical medicine; Disease Progression; Cytokines; Humans; Cyclin D1; Female; Demyelinating Diseases; Signal Transduction

To analyse whether the expression of apoptotic transcripts is associated with the conversion from clinically isolated syndrome (CIS) to multiple sclerosis (MS). Eleven candidate transcripts belonging to the death receptor pathway, BCL-2, the inflammasome complex and NF-ΚB family were studied in the nonconverting and converting CIS patients during the four-year follow-up period. Conversion to MS was associated with marked variability in the expression of proapoptotic genes that were linked to TGF-B1 gene levels. The predominant expression of proapoptotic genes in patients with CIS suggests an increased potential to undergo apoptosis with the goal of terminating immune responses and regulating immune system homeostasis.