EBV infected cells in the multiple sclerosis brain express PD-L1: How the virus and its niche may escape immune surveillance

• DOI: 10.1016/j.jneuroim.2024.578314
• Publication Date: 2024-02-15T05:18:56Z
• Authors: Barbara Serafini; Lucia Benincasa; Barbara Rosicarelli; Francesca Aloisi
• Keywords: Immune surveillance; Immune escape

The presence of EBV infected B cells in postmortem multiple sclerosis (MS) brain tissue suggests immune evasion strategies. Using immunohistochemical techniques we analysed the expression checkpoint molecule PD-L1 and its receptor PD-1 MS brains containing cell-enriched perivascular infiltrates meningeal follicles, a major reservoir. immunoreactivities were restricted to CNS-infiltrating cells. was expressed on cells, including while many CD8+ T EBV-specific T-cells, fewer CD4+ PD-L1+ close contact with PD-1+ by could favour local leading persistence immunopathology brain.