An increase of oxidized coenzyme Q-10 occurs in the plasma of sporadic ALS patients

• DOI: 10.1016/j.jns.2004.09.030
• Publication Date: 2004-12-15T04:14:45Z
• Authors: Makoto Sohmiya; Makoto Tanaka; Yoko Suzuki; Yutaka Tanino; Koichi Okamoto; Yorihiro Yamamoto
• Keywords: Adult; Aged, 80 and over; Male; 0301 basic medicine; Time Factors; Ubiquinone; Amyotrophic Lateral Sclerosis; Coenzymes; Bilirubin; Ascorbic Acid; Middle Aged; Statistics, Nonparametric; Uric Acid; 03 medical and health sciences; Case-Control Studies; Humans; Female; Oxidation-Reduction; Chromatography, High Pressure Liquid; Aged; Follow-Up Studies

We have compared plasma redox status of coenzyme Q-10 in 20 sporadic amyotrophic lateral sclerosis (sALS) patients with those in 20 healthy age/sex-matched controls. A significant increase in the oxidized form of coenzyme Q-10 (sALS=109.3+/-95.2 nM; controls=23.3+/-7.5 nM, P=0.0002) and in the ratio of oxidized form of coenzyme Q-10 to total coenzyme Q-10 (%CoQ-10) (sALS=12.0+/-9.3%; controls=3.2+/-0.9%, P<0.0001) were observed. Moreover, %CoQ-10 correlated significantly with the duration of illness (rho=0.494, P=0.0315). Our finding suggests systemic oxidative stress in the pathogenesis of sALS.