Bisphosphonate-Related Osteonecrosis of the Jaws–An Initial Case Series Report of Treatment Combining Partial Bone Resection and Autologous Platelet-Rich Plasma

• DOI: 10.1016/j.joms.2011.02.078
• Publication Date: 2011-07-23T01:26:39Z
• Authors: Marcos Martins Curi; Giuliano Saraceni...; Daniel Henrique Koga; Cristina Zardetto; Silmara Christianini; Olavo Feher; Camila Lopes Cardoso; Marcelo Oliveira ...
• Keywords: Adult; Aged, 80 and over; Male; Bone Density Conservation Agents; Diphosphonates; Platelet-Rich Plasma; Osteonecrosis; Bone Neoplasms; Middle Aged; 3. Good health; 03 medical and health sciences; Treatment Outcome; 0302 clinical medicine; Injections, Intravenous; Humans; Female; Jaw Diseases; Aged

Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a well-recognized pathologic entity that is challenging and difficult to manage. Recent literature contains several articles, with most recommending conservative management. This report describes a treatment modality for advanced cases of BRONJ that involves bone resection and autologous platelet-rich plasma (PRP).This case series consisted of 25 patients with BRONJ lesions and a history of intravenous bisphosphonate therapy for metastatic bone diseases that did not respond to conservative treatment. All patients were surgically managed by a standardized protocol combining bone resection and PRP.Of the 25 patients, 20 (80%) showed complete wound healing during follow-up. Median follow-up was 36 months. Microscopic examination showed actinomyces in 15 specimens.BRONJ has been shown to be refractory to conservative management. Treatment of refractory BRONJ with a combination of bone resection and PRP was found to be an effective therapy in most patients and should be considered an alternative treatment modality for management of advanced cases.