Associations of osteoclastogenesis and nerve growth in subchondral bone marrow lesions with clinical symptoms in knee osteoarthritis

• DOI: 10.1016/j.jot.2021.11.002
• Publication Date: 2021-12-01T04:48:35Z
• Authors: Feng Zhou; Xuequan Han; Liao Wang; Weituo Zhang; Junqi Cui; Zihao He; Kai Xie; Xu Jiang; Jingke Du; Songtao Ai; Qi Sun; Haishan Wu; Zhifeng Yu; Mengning Yan
• Keywords: Clinical pathology

Subchondral bone marrow lesions (BMLs) are common magnetic resonance imaging (MRI) features in joints affected by osteoarthritis (OA), however, their clinical impacts and mechanisms remain controversial. Thus, we aimed to investigate subchondral BMLs knee OA patients who underwent total arthroplasty (TKA), then evaluate the associations of osteoclastogenesis nerve growth with symptoms.Total 70 primary symptomatic were involved, separated into three groups based on MRI (without group, n ​= ​14; without cyst ​37; ​19). Volume cyst-like was calculated via OsiriX system. The Western Ontario McMaster Universities Osteoarthritis Index (WOMAC) questionnaire used assess symptoms. Histology immunohistochemistry deployed distribution. Pearson's correlation coefficient between volume joint symptoms, symptoms.In combined exhibited increased distribution bone, as shown expression tartrate resistant acid phosphatase (TRAP) protein gene product 9.5 (PGP9.5). component associated pain (p ​< ​0.05). positively group ​0.05).The lesion an independent factor for inducing patients; could account this pain.Our results indicated that joints. These findings may provide valuable basis treatment OA.