Neuroprotective effects of Ginkgo biloba dropping pills in Parkinson’s disease

• DOI: 10.1016/j.jpha.2020.06.002
• Publication Date: 2020-06-20T17:53:43Z
• Authors: Dingyi Yu; Pengli Zhang; Junying Li; Ting Liu; Yaodan Zhang; Qingqing Wang; Jianbing Zhang; Xiaoyan Lu; Xiaohui Fan
• Keywords: Pill

Parkinson's disease (PD) is the second most common neurodegenerative in world; however, it lacks effective and safe treatments. Ginkgo biloba dropping pill (GBDP), a unique Chinese G. leaf extract preparation, exhibits antioxidant neuroprotective effects has potential as an alternative therapy for PD. Thus, aims of this study were to evaluate GBDP vitro vivo PD models compare chemical constituents pharmacological activities EGb 761. Using liquid chromatography tandem-mass spectrometry, 46 identified. Principal component analysis identified differences profiles A quantitative 12 showed that had higher levels several flavonoids terpene trilactones than 761, whereas 761 organic acids. Moreover, we found prevented 6-hydroxydopamine-induced dopaminergic neuron loss zebrafish improved cognitive impairment neuronal damage methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mice. Although similar observed after treatment, greater treatment on endpoints. In addition, results suggested Akt/GSK3β pathway may be involved GBDP. These findings demonstrated have