Long-chain alkanol–alkyl carboxylic acid-based low-viscosity hydrophobic deep eutectic solvents for one-pot extraction of anthraquinones from Rhei Radix et Rhizoma

• DOI: 10.1016/j.jpha.2021.03.002
• Publication Date: 2021-03-18T20:57:19Z
• Authors: Anqi Huang; Wenwen Deng; Xiao Li; Qutong Zheng; Xuanxuan Wang; Yuxiu Xiao
• Keywords: Anthraquinones; Anthraquinones

Natural long-chain alkanol and alkyl carboxylic acid were used to prepare novel hydrophobic deep eutectic solvents (HDESs). These HDESs are liquid at room temperature have low viscosity (<12.26 mPa‧s), polarity (lower than that of methanol, ChCl-based other reported HDESs), density (<0.928 g/mL). A simple one-pot method based on a HDES-water two-phase extraction system was constructed for the weak-polarity bioactive components, anthraquinones, from Rhei Radix et Rhizoma. This HDES-based new does not consume hazardous organic can obtain total anthraquinone yield 21.52 mg/g, which is close obtained by Chinese pharmacopoeia (21.22 mg/g) considerably higher those HDESs-based methods (14.20-20.09 p < 0.01). The high be mainly attributed severe destruction RRR cell walls excellent dissolving ability anthraquinones.