Suicidal ideation in remitted major depressive disorder predicts recurrence

• DOI: 10.1016/j.jpsychires.2022.04.005
• Publication Date: 2022-04-11T16:37:40Z
• Authors: Caroline B.B.C.M....; Roel J.T. Mocking; Jasper B. Zantvoord; Caroline A. Figueroa; Aart H. Schene; Damiaan A.J.P. Denys; Henricus G. Ruhé; Claudi L.H. Bockting; Anja Lok
• Keywords: Depression; Longitudinal Study

Each year almost 800.000 people die from suicide, of which up to 87% are affected by major depressive disorder (MDD). Despite the strong association between suicidality and MDD, it remains unknown if suicidal symptoms during remission put remitted recurrent MDD patients (rrMDD) at risk for recurrence.At baseline we compared sociodemographic characteristics in un-medicated rrMDD participants matched never-depressed controls. We used HDRS17 IDS-SR30 assess symptomatology. Next, studied longitudinal time recurrence(s) a 2.5-year follow-up period using cox regression analyses. Further, with data whether symptomatology were cross-sectionally associated mixed model analysis.At baseline, (N = 73) had higher self-reported than controls 45) (χ2 12.09 p < .002). Self-reported four times (27.9% versus 6.9%) clinician-rated baseline. symptoms, but not predicted earlier MDD-recurrence follow-up, independent other residual 7.26, .026). Higher longitudinally related (HDRS17; F 49.87, .001), IDS-SR30; (F 22.36, .001).This study showed that - persist predict recurrence, symptoms. recommend monitor both rrMDD, preferably also including questionnaires apart clinician-rated. It would be beneficial future research primarily designed measuring ideation.