Cytokine levels in maternal and infant blood after COVID-19 vaccination during pregnancy in comparison with unvaccinated controls

• DOI: 10.1016/j.jri.2023.103821
• Publication Date: 2023-01-29T14:49:41Z
• Authors: Vishakha Sabharwal; Riley Demos; Jennifer Snyder-C...; Samantha E. Parker; Yazdan Shaik-Dast...; Jessica Hunnewell; Jeffery Boateng; Katherine Clarke; Rachel Yuen; Elizabeth Barnett; Christina Yarrington; Elizabeth Taglauer; Elisha M. Wachman
• Keywords: Cord blood

The objective of this study was to compare maternal and infant cytokine profiles at delivery among those vaccinated against SARS-CoV-2 during pregnancy to unvaccinated controls. Mother-infant dyads were enrolled in this prospective cohort study, and maternal blood and infant and/or cord blood collected. Samples were analyzed utilizing a LEGENDplex 13-plex human anti-viral response cytokine panel. Maternal IP-10 and IFN-λ2/3 were lower in the vaccinated cohort. In the infants, levels were lower for IL-1β, IFN-λ2/3, and GM-CSF, and higher for IFN-λ1 in the vaccinated cohort. Vaccination against SARS-CoV-2 during pregnancy did not lead to elevations in cytokines in mothers or infants.