Polymer-ceramic fiber nanocomposite coatings on titanium metal implant devices for diseased bone tissue regeneration

• DOI: 10.1016/j.jsamd.2021.04.001
• Publication Date: 2021-05-14T02:49:23Z
• Authors: Wensen Jing; Lei Feng; Bo Wang; Weisong Zhang; Ke Xu; Mohammed Saleh Al...; Suresh Mickymaray; Kan Peng
• Keywords: Biocompatibility; Polyvinyl Alcohol; Biomaterial

The osteoblast cell growth and cancer inhibition of titanium (Ti) metal implant coated with polyvinyl alcohol (PVA) reinforced hydroxyapatite (HAP) composite were investigated. fibrous PVA/HAP/folic acid (FA)/Methotrexate (MTX) was on the surface a plate observed microscopy. During PVA/HAP/FA/MTX composite's preparation, functional changes crystalline phases through Fourier-transform infrared spectroscopy X-ray diffraction analysis, respectively. fiber had an average diameter 19 nm greater mechanical strength (9660 Pa) than that pure HAP (4965 Pa), critical to scaffold under load-bearing applications. Biocompatibility, growth, proliferation capability studied in human bone marrow-derived stem cells (hBMSCs). found have excellent biocompatibility significant while MTX-loaded PVA/HAP/FA showed cytotoxicity against A459 cells. prepared composites will serve as superior biomaterial for osteosarcoma-diseased repair after evidencing in-vivo clinical trials.