Supported silver nanoparticles over alginate-modified magnetic nanoparticles: Synthesis, characterization and treat the human lung carcinoma

• DOI: 10.1016/j.jscs.2021.101393
• Publication Date: 2021-11-20T23:57:49Z
• Authors: Jing Huang; Jiquan Guo; Jiaxin Zhu; Xiaoling Zou
• Keywords: MTT assay; Viability assay

This article displays synthesis of Silver nanoparticles (Ag NPs) decorated on sodium alginate covered magnetite (Fe3O4/Alg-Ag nanocomposite. Sodium shell as a natural anionic polysaccharide Fe3O4 microparticles core acted stabilizing agent for the reduction Ag(I) ions into Ag NPs. The structural features synthesized nanocomposite were investigated by fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), field emission scanning electron microscopes (FE-SEM), transmission (TEM), energy-dispersive (EDX) and vibrating-sample magnetometer (VSM) studies inductively coupled plasma-optical (ICP-OES). 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay was used common lung cancer cell lines i.e., NCI-H1975, NCI-H1563, NCI-H1299 to survey cytotoxicity anti-lung effects had very low viability high activities dose-dependently against without any normal line (Human umbilical vein endothelial cells (HUVECs)). To determine antioxidant properties nanocomposite, 2,2-diphenyl-1-picrylhydrazyl (DPPH) test in presence butylated hydroxytoluene positive control. inhibited half DPPH molecules concentration 194 µg/mL. Maybe significant anti-human potentials human are linked their activities.