Excellent antimicrobial performances of Cu(II) metal organic framework@Fe3O4 fused cubic particles

• DOI: 10.1016/j.jscs.2023.101762
• Publication Date: 2023-10-24T16:14:09Z
• Authors: Riffat Ameen; Abdul Rauf; Ayesha Mohyuddin; Mohsin Javed; Shahid Iqbal; Sohail Nadeem; Komal Aroosh; Aziz ur Rehman Aziz; Ahmad Alhujaily; Randa A. Althobiti; Eman Alzahrani; Abd-ElAziem Farouk; Foziah F. Al-Fawzan; Eslam B. Elkaeed
• Keywords: Chemistry; Hydrothermal route; Cu-MOF@Fe3O4 nanocomposite; Antibacterial activity; Antibacterial mechanism; QD1-999; 01 natural sciences; 0104 chemical sciences

Metal-organic frameworks have been used as antibacterial agents because of their effective properties. In this research, nanocomposites copper (II)- benzene-1,4-dicarboxylic acid metal-organic framework with iron oxide [Cu-MOF@Fe3O4] were prepared via a simple hydrothermal route. X-ray analysis reveals the crystallinity structure while FTIR confirms existence Cu-based MOFs functional group. Cu-MOF@Fe3O4 scans using Scanning Electron Microscopy (SEM) reveal irregular clusters cubic particles fused Fe3O4 nanoparticles. Energy Dispersive (EDX) spectrum provides evidence elemental composition by showing peaks iron, oxygen, and carbon. Using minimum inhibitory concentration (MIC) zone inhibition assays, activity Cu-MOF against E. coli B. subtilis evaluated. The results shown that has higher performance compared to Cu-MOF, ligands only. On other hand, composites exhibit excellent antifungal potential when ligand, commercial nanoparticles, Cu(NO3)2.3H2O, oxide, Cu-MOF. exploration mechanism revealed composite favors slow release metal ions prolonged biocidal effect.