The inflammatory response of the supraspinatus muscle in rotator cuff tear conditions

• DOI: 10.1016/j.jse.2020.08.028
• Publication Date: 2020-09-29T09:50:48Z
• Authors: Lars Henrik Frich; Livia Rosa Fernandes; Henrik Daa Schrøder; Eva Kildall Hejbøl; Pernille Vinther ...; Puk Hvirgel Jørge...; Allan Stensballe; Kate Lykke Lamber...
• Keywords: Infiltration (HVAC); Supraspinatus muscle; Rotator cuff injury

BackgroundRotator cuff (RC) disorders involve a spectrum of shoulder conditions from early tendinopathy to full-thickness tears leading impaired function and pain. The pathology RC disorder is, nonetheless, still largely unknown. Our hypothesis is that supraspinatus (SS) tendon tear leads sustained inflammatory changes the SS muscle along with fatty infiltration degeneration, which are threshold markers for poor function. aim this study was determine extent inflammation in conjunction lipid accumulation fibrosis conditions.MethodsWe used proteomics, histology, electrochemiluminescence immunoassay, quantitative polymerase chain reaction analyses evaluate degenerative biopsies 22 patients undergoing surgery repair tear.ResultsBioinformatic analysis showed proteins involved innate immunity, extracellular matrix organization, metabolism were among most upregulated, whereas mitochondrial electronic transport fiber downregulated. Histologic confirmed organization presence infiltration. Inflammation appeared be driven by high number infiltrating macrophages, accompanied elevated metalloprotease levels transforming growth factor-β cytokine compared deltoid muscle.ConclusionsWe demonstrated massive after combined degeneration. regulation tissue thus extremely complex, it may have opposite effects at different time points healing. Inhibition or stimulation potential target enhance outcome repaired torn RC. Rotator conditions. We tear. Bioinformatic muscle.