The practical approach to the evaluation of methods used to determine the disintegration time of orally disintegrating tablets (ODTs)

• DOI: 10.1016/j.jsps.2015.01.015
• Publication Date: 2015-01-16T16:45:14Z
• Authors: Witold Brniak; Renata Jachowicz; Przemyslaw Pelka
• Keywords: Distilled water

Even that orodispersible tablets (ODTs) have been successfully used in therapy for more than 20 years, there is still no compendial method of their disintegration time evaluation other the pharmacopoeial test conducted 800-900 mL distilled water. Therefore, several alternative tests relevant to vivo conditions were described by different researchers. The aim this study was compare these methods and correlate them with results. Six series ODTs prepared direct compression. Their mechanical properties times measured compared highest correlation oral found case own-construction apparatus additional weight employment proposed Narazaki et al. coefficients 0.9994 (p < 0.001), 0.9907 0.001) respectively. correlated data much worse (r = 0.8925, p 0.05). These results shown development novel biorelevant ODT's determination eligible scientifically justified.