Hybrid polymeric matrices for oral modified release of Desvenlafaxine succinate tablets

• DOI: 10.1016/j.jsps.2016.10.005
• Publication Date: 2016-10-19T15:10:30Z
• Authors: Wael Samy; Ayman Elnoby; Hanan M. El-Gowelli; Nazik Elgindy
• Keywords: Excipient; Matrix (chemical analysis); Maltodextrin

Purpose: Desvenlafaxine succinate (DSV) is a water soluble anti-depressant drug, which rapidly absorbed after oral administration exaggerating its side effects. The current work aimed to prepare controllable release DSV matrix reduce effects related initial burst. Methods: Fifteen formulations were prepared using different polymers, polymer/drug ratios and excipients characterized Differential Scanning Calorimetry (DSC), infrared (IR) spectroscopy, uptake in vitro release. kinetics calculated determine the drug mechanism. Ex-vivo absorption via rat intestinal mucosal cells calculation of apparent permeability coefficient (Papp) performed everted sac technique. Results: Maltodextrin was best excipient (F7 F10) showing acceptable decrease burst compared innovator. addition negatively charged polymers sodium carboxy methyl cellulose (SCMC) or alginate resulted an interaction that proved by DSC IR findings. This slowed F10 showed excellent more than 80% 4 h highest similarity factor with innovator (84.7). Conclusion: A pattern achieved Methocel, SCMC. obtained results could be used as platform control cationic drugs suffer from associated their administration.