Effect of combined gliclazide/metformin treatment on oxidative stress, lipid profile, and hepatorenal functions in type 2 diabetic patients

• DOI: 10.1016/j.jsps.2017.11.007
• Publication Date: 2017-11-15T00:49:23Z
• Authors: Mansour Alsharidah; Metab. Algeffari; Abdel-Moneim Hafe...; Mohamed Faisal Lutfi; Haila Alshelowi
• Keywords: Gliclazide; Lipid Profile

Type 2 diabetes is a chronic condition that requires pharmacotherapy interventions. Metformin and gliclazide are widely used drugs in monotherapy. However, their complementary action made utilization of the combination these an appealing approach.The study compared major therapeutic potentials combined metformin/gliclazide treatment over metformin monotherapy based on following parameters: oxidative stress, lipid profile, hepatorenal functions.This comparative was conducted from March 2015 to 2016. The screened 80 type diabetic patients, which 40 patients underwent + therapy (500 mg BD OD, respectively). other were matched for age duration mellitus with previous group received BD). levels fasting blood glucose (FBG), total glycated hemoglobin (HbA1c), peroxidation, antioxidant capacity, serum creatinine, aspartate alanine transaminases, cholesterol, triglycerides, high-density lipoproteins, low-density lipoproteins measured according standard methods.Oxidative functions comparable both groups. showed significantly lower FBG [7.61 (6.70-8.89) mmol/L vs. 9.00 (7.30-10.68) mmol/L; P = .022] HBA1c [7.00 (6.40-7.65)% 8.20 (7.20-9.75)%; < .001] those therapy.Oxidative lipids not different who alone. In contrast, glycemic control poor undergoing therapy.